Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Romitti M, Tourneur A, de Faria da Fonseca B, Doumont G, Gillotay P, Liao XH, Eski SE, Van Simaeys G, Chomette L, Lasolle H, Monestier O, Kasprzyk DF, Detours V, Singh SP, Goldman S, Refetoff S, Costagliola S.

Nature Communications, 2022. Nov 17;13(1):7057.

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Functional Thyroid Organoids—Powerful Stem Cell-Derived Models in Basic and Translational Research.

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Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids