Mirian Romitti 9/4/25 Mirian Romitti 9/4/25

NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Development of 3D organoid models to study aggressive thyroid cancers

Rios-Morris E, Tientcheu Ngaffi VI, Costagliola S, Romitti M.

Eur Thyroid J. 2025 Jul 2;14(4):e240392.

doi: 10.1530/ETJ-24-0392.

Mirian Romitti 9/4/25 Mirian Romitti 9/4/25

Transcriptomics of autoimmune diseases identifies FGFR1 as a target for pancreatic β-cell protection

Yi X, Zimath PL, Martin-Vazquez E, Oliveira JG, Jawurek S, Title AC, Yesildag B, Mourad NI, Buemi A, Pattou F, Kerr-Conte J, Costagliola S, Romitti M, Eizirik DL.

J Autoimmun. 2025 Aug 8;156:103469.

doi: 10.1016/j.jaut.2025.103469.

Mirian Romitti 5/21/25 Mirian Romitti 5/21/25

Functional Thyroid Organoids—Powerful Stem Cell-Derived Models in Basic and Translational Research.

Shankar MP, Boggian A, Aparicio-Quiñonez D, Djerbib S, Rios-Morris E, Costagliola S, Romitti M.

Biomolecules. 2025; 15(5):747. https://doi.org/10.3390/biom15050747

Mirian Romitti 3/17/25 Mirian Romitti 3/17/25

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Romitti M, Tourneur A, de Faria da Fonseca B, Doumont G, Gillotay P, Liao XH, Eski SE, Van Simaeys G, Chomette L, Lasolle H, Monestier O, Kasprzyk DF, Detours V, Singh SP, Goldman S, Refetoff S, Costagliola S.

Nature Communications, 2022. Nov 17;13(1):7057.

Aleks 3/17/25 Aleks 3/17/25

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Lasolle H, Schiavo A, Tourneur A, Gillotay P, de Faria da Fonseca B, Ceolin L, Monestier O, Aganahi B, Chomette L, Kizys MML, Haenebalcke L, Pieters T, Goossens S, Haigh J, Detours V, Maia ALS, Costagliola S, Romitti M.

Oncogene. 2024 Jan;43(3):155-170.

Mirian Romitti 3/17/25 Mirian Romitti 3/17/25

Mesodermal FGF and BMP govern the sequential stages of zebrafish thyroid specification

Haerlingen B, Opitz R, Vandernoot I, Molinaro A, Shankar MP, Gillotay P, Trubiroha A, Costagliola S.

Development. 2023 May 15;150(10):dev201023.

Aleks 3/17/25 Aleks 3/17/25

STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179

Grasberger H, Dumitrescu AM, Liao XH, Swanson EG, Weiss RE, Srichomkwun P, Pappa T, Chen J, Yoshimura T, Hoffmann P, França MM, Tagett R, Onigata K, Costagliola S, Ranchalis J, Vollger MR, Stergachis AB, Chong JX, Bamshad MJ, Smits G, Vassart G, Refetoff S.

Nat Genet. 2024 May;56(5):877-888.